Senior Scientist, Discovery Biology Retinal Diseases

4 days left

Employer
Merck
Location
South San Francisco, California, US
Salary
Competitive
Posted
Jul 19, 2021
Closes
Aug 01, 2021
Ref
2326464000
Discipline
Biology, Genetics
Employment Type
Full time
Salary Type
Salary
Job Description
Our company's Research Laboratories in South San Francisco is a brand-new innovation hub designed to foster collaboration between scientists to discover new medicines to improve human health. Retinal Diseases Discovery Biology group is seeking a driven and creative Senior Scientist to join our drug discovery team. This is an exciting opportunity for an independent scientist to drive target identification and validation activities in close collaboration with colleagues in Biology, Chemistry and Biologics teams at our Research Division's South San Francisco and across broader company network. The ideal candidate will be an accomplished scientist with proven track record high impact research in retinal diseases with direct hands-on experience with state of the art in vitro pre-clinical models of dry Age-Related Macular Degeneration (AMD). This position requires high level of motivation and enthusiasm for drug discovery coupled with the ability to plan and execute experiments focused on novel target discovery and validation in a highly collaborative environment.
A successful candidate will be responsible for:
- Developing innovative drug targets to address high unmet medical need in dry AMD
- Designing and implementing platforms for target identification and validation utilizing in vitro cell-based assays focused on retinal pigment epithelial (RPE) cell biology
- Providing necessary support to clinical and translational biomarkers groups
- Independently managing functional deliverables for discovery program(s)
- Mentoring and developing junior scientists
- Establishing and maintaining effective collaborations with internal and external partners, including leading academic laboratories
- Providing scientific expertise in retinal diseases to help formulate drug discovery strategy
Education Minimum Requirement
- Ph.D. in Molecular Biology, Immunology, Genetics or related biological discipline and at least 3 years of post-doctoral training
Required Skills and Experience
- Evidence of scientific productivity based on publications, presentations and patents
- Hands on experience with in vivo and in vitro models of dry AMD including human iPSC derived RPE cell lines
- Deep knowledge of molecular pathways driving RPE and photoreceptor degeneration in AMD
- Ability to solve complex biological problems by undertaking innovative approaches and applying state-of-the-art technologies including CRISPR/Cas9 tools
- Expertise in molecular and cellular biology, cell-based assay, and ex vivo sample processing and analysis
- Excellent oral presentation and communication skills.
Preferred Skills
- Experience with target ID and validation in an industry setting
- Deep understanding of retina/RPE/choroid tissue homeostasis and metabolism
- Experience with various -omics technologies and their application for target discovery (NGS technologies, proteomics and metabolomics)
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are ...
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for ...
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization.
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
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US and Puerto Rico Residents Only:
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Pay Transparency Nondiscrimination
We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
No Travel Required
Flexible Work Arrangements:
Work Week
Shift:
Not Indicated
Valid Driving License:
Hazardous Material(s):
Number of Openings:
1
Requisition ID: R129678

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