Computational Biologist, Clinical Bioinformatics

Dana Farber Cancer Institute
Boston, Massachusetts, US
Jul 09, 2021
Aug 01, 2021
Employment Type
Full time
Salary Type
The NGS Bioinformatics Group at Dana-Farber Cancer Institute seeks a Computational Biologist to work on Profile, our institutional comprehensive precision cancer medicine initiative. The candidate will work on developing NGS bioinformatic workflows and modules for the analysis of rich and complex somatic and germline data from the Profile project and contribute towards taking our precision oncology efforts to the next level.

This group is a part of the Department of Data Sciences at Dana-Farber Cancer Institute aimed at driving cancer research through innovation and collaboration in the quantitative sciences. The department is unified by a commitment to improving cancer care through data-driven approaches. We strive to understand the biology of cancer, test the efficacy of treatments and extract knowledge from complex datasets.

Located in Boston, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


Develop reproducible bioinformatic pipelines for institutional NGS cancer sequencing efforts, including targeted capture assays, RNA-seq, whole exome, whole genome and cfDNA
Benchmark and validate bioinformatics tools and algorithms using public and in-house samples
Integrate data from public databases into the group's pipelines and analyses
Interface with the Bioinformatics Platform Group, which will be developing a new scalable, cloud-based platform for running all NGS sequencing pipelines
Effectively communicate results to immediate collaborators and to the larger bioinformatic and clinical communities


Bachelor's degree required. MS in bioinformatics, computer science and/or the life sciences a plus
2-3 years of relevant experience
Hands-on experience in NGS data analyses using state-of-the-art tools and methods
Proficiency in Python, R/Bioconductor, and Bash in high-performance computing environments
Experience with workflow standards such as WDL/CWL and workflow execution engines such as Cromwell
Strong interest in contributing to biological research and cancer genomics

The candidate must demonstrate excellent communication skills, outstanding personal initiative and the ability to work effectively as part of a team. Ability to meet deadlines and efficiently multitask is a must.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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