Scientist I (mRNA / Molecular Biology)

CSL Behring
Cambridge, Massachusetts, US
Jun 27, 2021
Sep 01, 2021
Employment Type
Full time
Salary Type
With operations in 35+ nations and ~27,000 employees worldwide, CSL is driven to develop and deliver a broad range of lifesaving therapies to treat disorders such as hemophilia and primary immune deficiencies, and vaccines to prevent influenza. Our therapies are also used in cardiac surgery, organ transplantation and burn treatment.

CSL is the parent company of CSL Behring and Seqirus. CSL Behring is a global leader in the protein biotherapeutics industry, focused on bringing to market biotherapies used to treat serious and often rare conditions. CSL Behring operates CSL Plasma, one of the world's largest collectors of human plasma, which is used to create CSL's therapies. Seqirus is one of the largest influenza vaccine companies in the world and is a transcontinental partner in pandemic preparedness and a major contributor to the prevention and control of influenza globally.

We invite you to take a look at the many career possibilities available around the globe and consider building your promising future at CSL by becoming a member of our team!
Job Description
Job Summary:

This position is responsible for developing and performing cell-based assays to assess the biological performance of vaccine candidates, performing mRNA synthesis and characterization, and supporting various areas of molecular biological assays.

Major Accountabilities:
RNA and LNP potency testing
  • Perform cell-based assays for evaluation of mRNA-based vaccine candidates.
  • Develop and perform novel cell-based assays for candidate screening.

mRNA production and molecular biology assays.
  • Support cloning, RNA production and characterization.
  • Support molecular biology assay development, such as qPCR and ddPCR.

Documentation and presentation of scientific results.
  • Write experimental protocols and prepare internal reports. Maintain lab notebooks.
  • Collaborate with project teams, present research results and contribute to technical advancements and publications.

Lab management.
  • Maintain functional laboratory equipment and keep up with ordering and lab organizing.

Minimum Requirements:
  • Bachelor or Master's degree in cell biology, RNA biology or molecular biology.
  • BS with 5-7+ years experience, or MS with 3-5+ years of academic or pharmaceutical/biotech experience in cell biology, RNA biology or molecular biology.
  • Strong experience in cell culture, including maintaining cell lines and primary cells, building new cell lines, and performing transfection and cell-based assays is required.
  • Experience with RNA transcription and purification is desired.
  • Experience in molecular cloning, sequence analysis, DNA/RNA quantification such as qPCR is desired.
  • Creative and the ability to generate accurate and reproducible results along with multi-tasking and working effectively in a fast-paced environment are critical.
  • Organizational, written and oral communication skills and ability to work in teams is required.