Scientist I, Assay Development Molecular and Cell Biology vs

Employer
Adverum Biotechnologies
Location
Portola Valley, California, US
Salary
Competitive
Posted
Jun 25, 2021
Closes
Jul 28, 2021
Ref
2326150378
Field
Development
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
Adverum is looking for a Scientist I with knowledge of Molecular and Cell biology to join our team in our Redwood City office. This position reports to Senior level personnel in the Assay Development group. This person will be working cross functionally with Quality Control, and Process Development groups. This role is responsible for developing, qualifying, transferring, and troubleshooting molecular and cell-based assays in support of product characterization and release.
What you'll do:
  • Plan strategies for and participate in the development, qualification, and transfer of quantitative and semi-quantitative molecular and cell-based bioanalytical methods to support product release
  • Participate in the transfer of processes, technology, and assays to/from internal and external collaborators and contract research organizations
  • Participate in the transfer of assays to Quality Control and training Quality Control personnel.
  • Present results, conclusions, and implications to project teams and senior management
  • Maintain a detailed awareness of industry guidance and standards for assay validation and performance
  • Maintain current knowledge of advancing technologies and propose their applications to ongoing projects.
  • Author standard test methods and best-practices documents for the Assay Development group
  • Contribute to development reports
  • Contribute to CMC protocols and regulatory reports
  • Independently plan, implement, and complete significant projects with minimal supervision.
  • Participate in decisions on experimental approaches and interpretation of data.
  • Work collaboratively with different research and development departments to evaluate and implement new assay formats and/or technologies.
  • Participate in scientific meetings and produce original peer-reviewed publications.
  • Maintain excellent documentation of laboratory activities.
  • Other responsibilities may be assigned as needed.

About you:
  • PhD degree and 2+ years relevant biotechnology industry experience, Master's degree and 10+ years relevant biotechnology industry experience. Bachelor's degree with exceptional experience in biologics assay development and 15+ years relevant biotechnology industry experience
  • Experience in developing and validating molecular and cell-based product release assays is required. Knowledge of FDA requirements desired.
  • Experience working as part of a project team
  • Understanding of QC assay requirements
  • Ability to read and extract information from published literature and internal reports is required.
  • Expertise is required in molecular assays (DNA/RNA extraction, Reverse transcription, ddPCR, qPCR, primer design) and cell-based assays (sterile tissue culture techniques, transfection, transduction, maintaining, subcloning, and banking cells).
  • Broad knowledge of cell assay methods and biochemistry with application to gene therapy (for example, neutralizing antibody assays) is strongly desired.
  • Background in virology and AAV biology is strongly desired. Knowledge of retinal or genetic diseases is a plus
  • Must be a self-starter, proactive, co-operative, and proficient at working both independently and in a small team environment.
  • Proven initiative and demonstrated accountability in a fast-paced environment with high degree of flexibility.
  • Detail oriented with time management skills.
  • Excellent verbal and written communication skills.
  • Experience in presenting data through written reports and oral presentation.
  • Publication in a peer-reviewed journal or presentation at a conference is desired.
  • Proficiency with SoftMaxPro, GraphPad Prism, JMP, and other common analytical software desired.
  • Proficient with MS Office and other common office software.

About Us
Adverum is a clinical-stage gene therapy company targeting unmet medical needs in ophthalmology and rare diseases. Adverum develops gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein. Adverum's core capabilities include clinical development, novel vector discovery and in-house manufacturing expertise, specifically in scalable process development, assay development, and current Good Manufacturing Practices quality control.

At Adverum, Inclusion and Diversity are at our core. We believe in the power of being your authentic self. We strive to create the space which allows for everyone in our Adverum Community to not only feel safe but encouraged to speak, learn from each other, grow in their professions and be the very best versions of themselves no matter what their age, ethnic background, gender, origin, religion or sexual orientation

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