Computational Biologist, Sr. I - Cell-Free DNA (cfDNA) Informatics Team

Employer
Memorial Sloan Kettering
Location
Grand Central, New York, US
Salary
Competitive
Posted
Jun 25, 2021
Closes
Jul 25, 2021
Ref
2276874172
Discipline
Genetics
Employment Type
Full time
Salary Type
Salary
At Memorial Sloan Kettering (MSK), we're not only changing the way we treat cancer, but also the way the world thinks about it. By working together and pushing forward with innovation and discovery, we're driving excellence and improving outcomes. We're treating cancer, one patient at a time. Join us and make a difference every day.


Please note that effective July 1, 2021, MSK will require all new hires, volunteers, and vendors who come onsite to provide proof of COVID-19 vaccination. This is based on the COVID-19 vaccines' high level of protection and our shared responsibility in protecting our patients.

Are you passionate about working with an expanding team of research, clinical and computational investigators developing cutting-edge diagnostic technologies in cancer genomics?

Then join us here at MSK, where we can provide you with the opportunity to make a difference with your career. We believe that this is an exciting role for someone who has the right background to be a part of our dynamic team and who wants to apply their skills to support our mission here!

The Cell-Free DNA (cfDNA) Informatics Team in the MSK Center for Molecular Oncology (CMO) is searching for a talented self-driven Computational Biologist to build workflows, evaluate tools and analyze circulating tumor DNA sequencing data.

The CMO promotes precision oncology through genomic analysis to guide the diagnosis and treatment of cancer patients. We bring together clinicians and scientists throughout Memorial Sloan Kettering Cancer Center to conduct large-scale translational research involving molecular characterization of patient tumor specimens to identify correlations between genomic features and clinical outcomes.

Under the supervision of the group leader, the Computational Biologist will work closely with members of the CMO Innovation lab, Molecular Diagnostics Service, and other CMO teams and research labs to build workflows, evaluate tools and perform analysis of data generated by the MSK-ACCESS assay, a comprehensive liquid biopsy test that offers noninvasive cancer genomic profiling and disease monitoring. It involves the deep sequencing of 129 key cancer-associated genes selected from MSK's solid tumor genomic-profiling assay, MSK-IMPACTâ„¢. MSK-ACCESS is designed to detect genetic alterations in cfDNA specimens such as blood and other body fluids.

You Will:

  • Process and analyze data from high-throughput next-generation sequencing
  • Design, develop, and operate software tools and databases as part of bioinformatics data processing and analysis system
  • Be responsible for program design, coding, testing, debugging, and documentation
  • Evaluate results and diagnose issues with new analyses
  • Monitor and evaluate new developments in the field of computational biology and bioinformatics in order to apply these methods to data analyzed within the Center
  • Collaborate with clinical and translational researchers, as well as other bioinformatics scientists and software engineers, at the Center
  • Train researchers in the use of computational and bioinformatics tools and interpretation of results, and develop training modules


You Are:

  • Intrinsically motivated by a desire to perform analyses and develop software that will advance science and make a positive societal impact
  • Excited by new datasets and the opportunity to look at data in new ways
  • Capable of building strong customer relationships and delivering customer-centric solutions
  • A good decision-maker, with proven success at making timely decisions that keep the organization moving forward
  • Able to work effectively in an environment notable for complex information, dynamic priorities, and multiple stakeholders
  • Consistently achieving results, even under tough circumstances
  • Adept at planning and prioritizing work to meet commitments aligned with organizational needs
  • Adept at building partnerships and working collaboratively with others to meet shared objectives and goals
  • An effective communicator, capable of determining how best to reach different audiences and executing communications based on that understanding
  • Resilient in recovering from setbacks and skilled at finding detours around obstacles
  • Able to work both independently and collaboratively, making necessary connections with experts in various biological and clinical groups


You Need:

  • Master's in biological science, mathematics, physics, bioinformatics or related discipline with a strong quantitative background and 2-4 years' experience OR Ph.D. with 0-2 years' experience
  • Experience working with large numbers of samples and modern workflow management frameworks (Snakemake, Cromwell/CWL/WDL, NextFlow, etc) running on either HPC systems (e.g. using LSF) or on cloud services (e.g. AWS or GPC)
  • Proficiency with scientific computing software (Python, R) and scripting languages
  • Research experience in statistical genetics/genomics strongly preferred and familiarity with next-generation sequence data and analysis tools required
  • Familiarity with databases (SQL or NoSQL), git, svn, or another version control system
  • Excellent oral and written English communication skills; experience in delivering oral scientific presentations and writing scientific articles strongly preferred.


Benefits

Competitive compensation packages | Sick Time |Generous Vacation+ 12 holidays to recharge & refuel| Internal Career Mobility & Performance Consulting | Medical, Dental, Vision, FSA & Dependent Care|403b Retirement Savings Plan Match|Tuition Reimbursement |Parental Leave & Adoption Assistance |Commuter Spending Account |Fitness Discounts &Wellness Program | Resource Networks| Life Insurance & Disability | Remote Flexibility

We believe in communication, openness, and thinking beyond your 8-hour day @ MSK. It's important to us that you have a sense of impact, community, and work/life balance to be and feel your best.

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MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.

Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.

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