Structural Biologist/NMR Spectroscopist

Our client is urgently hiring for NMR Spectroscopy/ Structural BiologistDESCRIPTION:Position SummaryThis role will make essential contributions to our structural biology drug discovery efforts using both external and internal resources. One of the primary responsibilities is to profile small molecule interactions with RNA starting with 1-D NMR and ultimately 3-D NMR to map the small molecule binding site to RNA. You will play a key role in the design and synthesis of RNA constructs as well as interpret NMR spectra to assign binding poses of small molecules to RNA to provide important structural information. A key aspect of this position is teamwork and the ability to collaborate with chemists, modelers, and the assay group to create and maintain a cohesive strategy to use structural biology to drive our medicinal chemistry efforts.Primary Responsibilities Design, synthesize and purify stably isotope-labeled RNA constructs in quantities suitable for NMR structural studies. Collect preliminary NMR data of ligands and their complexes with RNA to determine the feasibility of structural studies. Using internal and external resources, collect, process, and analyze multi-dimensional NMR spectra of RNA/ligand complexes with optimized sample and experimental parameters for the purposes of 3-D structure determination. Determine the structure of RNA /ligand complexes using NMR data as input into a state-of-the-art software package. (i.e., CYANA, AMBER, etc.) Work with project teams in using the structural data to facilitate and accelerate medicinal chemistry efforts Clearly document experimental efforts and results by both oral presentation and written reports.SKILLS:rna, nmr spectroscopy, Data analysis, analysisTOP SKILLS DETAILS:rna,nmr spectroscopyADDITIONAL SKILLS & QUALIFICATIONS:Qualifications Ph.D. in biophysics, chemistry, structural biology or related field or M.S. and 4 years structural biology experience. Experience in the synthesis and purification of stable isotope-labeled RNA using enzymatic in vitro transcription methods. Expertise in solution structure determinations of RNA by NMR, including data acquisition, spectral analysis, and computing structures from NMR spectroscopic parameters. Excellent written and oral communication skills. Ability to work independently and collaborate in a multi-disciplinary environment. Experience with in vitro binding assays and biophysical techniques is a plus. Experience in x-ray crystallography of RNA is a plus.EXPERIENCE LEVEL:Intermediate Level ABOUT AEROTEK: We know that a company's success starts with its employees. We also know that an individual's success starts with the right career opportunity. As a Best of Staffing Client and Talent leader, Aerotek's people-focused approach yields competitive advantage for our clients and rewarding careers for our contract employees. Since 1983, Aerotek has grown to become a leader in recruiting and staffing services. With more than 250 non-franchised offices, Aerotek's 8,000 internal employees serve more than 300,000 contract employees and 18,000 clients every year. Aerotek is an Allegis Group company, the global leader in talent solutions. Learn more at .

The company is an equal opportunity employer and will consider all applications without regards to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.