Research Associate - Neurobiology

South San Francisco, California, US
Jun 18, 2021
Jun 22, 2021
Biology, Genetics
Employment Type
Full time
Salary Type
Research Associate - Neurobiology If you are looking to make an impact as a Research Associate or Sr. Research Associate at an exciting, early-stage venture-backed biotech company, please read on.

We are an early-stage venture-backed biotech company based in South San Francisco. Our revolutionary chemogenetic platform aims to control the activity of cells to treat disease. We are growing rapidly and adding talented individuals to our team of industry leaders.

If you have 1-2+ years' post-grad lab research experience (academic or industry), within a similar space, this is the role for you.
Top Reasons to Work with Us - Revolutionary platform
- Fast-paced environment
- Work with industry leaders
What You Will Be Doing You will work under the guidance of a scientist to support selection and characterization of engineered ligand-gated ion channel candidates via in vitro imaging and electrophysiology assays. You will bring significant experience in neuronal primary culture, including tissue harvest, cell culture and in vitro viral vector transduction along with an enthusiastic approach to research.
- Tissue Harvest: Dissection of CNS and PNS tissue from rodents and isolation of cell-bearing areas for downstream primary culture purposes. Areas of interest include sensory neuron ganglia and hippocampus.
- Neuronal Cell Culture: Preparing, maintaining and troubleshooting one or more rodent primary neuronal subtypes in culture and preparing and maintaining cultures from human primary sensory neuronal tissue. Culture, maintain and troubleshoot two or more human IPSC-derived neuronal cell lines.
- In vitro Transductions: Perform transductions of neuronal cultures using AAV-based viral vectors, and oversee stocks of virus. Maintaining, transfecting, and transducing IPSC-derived/standard mammalian cell lines. Design and execute experiments for culture and transduction condition optimization.
- In vitro Imaging Assays: Perform immunocytochemistry and live-cell based assays in support of engineered ligand-gated ion channel candidate characterization.
- General Lab Duties: Fulfilling company-wide drug compound requests; making solutions, buffers, and compound dilutions to support electrophysiology and cellular & molecular neuroscience; ordering, receiving and stocking supplies, inventory tracking, and representing group in company stockroom committee.
What You Need for this Position - B.S or M.S. in Cell Biology or a closely related field
- 1-2+ years of post-degree research experience in an academic or industry setting.
- Expertise/Experience in harvesting, isolating and culturing of primary neurons from rodents
- Culturing and differentiation of human iPSCs.
- Mammalian cell culture, transfection and transduction, including IPSC-derived neuronal cells
- Working with viral vectors (AAV, HSV, LV).
- Experience with immunofluorescence and other imaging-based in vitro assays.
Desired/Sr. Research Associate Level Experience
- 2-3+ years of post-degree research in an industry setting
- Ion Channels, GPCRs, chemogenetics, and/or optogenetics
- Gene Expression constructs, basic molecular biology (PCR, cloning) and biochem (western blotting)
- Quantitative Analysis of imaging data
- Data Processing and Analysis - programming/scripting (Python, R, ImageJ)

Software/Technical Skills:
- Common laboratory equipment (balances, pH meter, osmometer, etc.) and common lab practices and safety.
- MS office, data plotting and graphing software (e.g. Prism) and ability to communicate results effectively.
What's In It for You Competitive Compensation and Benefits
- 80-105K - Research Associate
- 100 - 125K - Sr. Research Associate
- 10% Bonus
- Meaningful Equity
- Health, Dental, Vision
- Generous PTO
So, if you are a Research Associate with relevant experience, please apply today.
- Applicants must be authorized to work in the U.S.

*CyberCoders, Inc is proud to be an Equal Opportunity Employer*

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, protected veteran status, or any other characteristic protected by law.

*Your Right to Work* - In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification document form upon hire.

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