Head of RNA Biology

Seattle, Washington, US
Jun 17, 2021
Jun 20, 2021
Employment Type
Full time
Salary Type
We are seeking an experienced and creative leader to join our interdisciplinary R&D team with the focus on product development of therapeutic nucleic acids. This candidate will take the leading role within the R&D group to develop new products and applications. He/she will also drive collaboration and communication with our production team and biologics department.

Key Responsibilities:
  • Lead a cross-functional team to propose, design, plan, and manage R&D projects with focus in gene and RNA therapeutics applications
  • Develop and optimize large scale DNA and RNA production process
  • Lead the research efforts on RNA design, modifications, and protein translation for mRNA and circular RNA.
  • Synthesis and characterization of RNA and DNA constructs
  • Define QC methods for the developed products/service
  • Collaborate with and/or supervise the scientists and engineers on joint projects
  • Transfer developed technologies to the production team and provide support as needed for process improvement, scale-up or troubleshooting
  • Perform statistical data analysis and present the results

  • Ph.D. in Biochemistry, Molecular Biology, Synthetic Biology, Microbiology, Biomedical Engineering, or related biomedical field with a minimum of 6 year experience in the pharmaceutical company, biotech or related industries
  • Track record of success in RNA assay and product development
  • Expert in RNA biology and RNA chemistry including structure simulation, design, modification and stability improvement
  • Strong molecular biology laboratory skills. Experience in nucleic acid amplification, in vitro transcription, primer/probe/vector design, enzymatic reactions, PCR, qPCR, next-generation sequencing, molecular cloning and large scale plasmid preparation
  • Knowledgeable in nucleic acid chemistry, molecular/cellular mRNA metabolism and translation mechanism
  • Proven ability to analyze multi-factorial data, provide conclusions and design next steps independently.
  • Experience in process development for cGMP-compliant therapeutic nucleic acid production is preferred
  • Experience w 31115000 ith automation platforms is a plus
  • Demonstrated initiative and pursuit of successful collaborative research projects with interdisciplinary team
  • Demonstration of goal-oriented, hands-on and innovative approach to problem solving