Senior Scientist, Molecular Biology and Virology

Senior Scientist

Oncorus is a clinical-stage biotechnology company focused on developing next-generation viral immunotherapies to transform outcomes for cancer patients. Based in the vibrant Kendall Square, MA biotech ecosystem and backed by group of leading institutional life sciences investors, we are advancing a portfolio of intratumorally and intravenously administered viral immunotherapy candidates based on our oncolytic herpes simplex virus-1 and synthetic virus platforms for multiple indications with significant unmet needs. Our team is driving innovation and engineering multiple candidates with both platforms to potentially enable us to deliver on the full potential of this exciting therapeutic class. We believe every cancer patient deserves a better outcome. And we are working with urgency to make that happen. Please visit www.oncorus.com to learn more.

Overview:

Oncorus is seeking an experienced Senior Scientist to join our Molecular Biology and Virology group. The successful candidate will join a multidisciplinary team that is focused on the discovery and validation of novel viral oncolytics, and will be responsible for implementing a research plan geared towards developing a mechanistic understanding of virus-host interactions and how they can be manipulated to generate a beneficial therapeutic response. Current efforts of the team are focused on the engineering and optimization of HSV-1 virus platform for application in glioblastoma and other tumors of the CNS. Applicants should have established expertise in cancer biology as well as a demonstrated by a track record of high-impact publications.

Summary of Key Responsibilities:

• Engineering of viral gene transfer vectors and cell lines using established molecular biology techniques. Hands on expertise using siRNA/shRNA gene knockdown and CRISPR/Cas gene knockout technologies is highly desirable
• Development and implementation of relevant assays to confirm gene delivery and subsequent phenotypic changes associated with payload expression
• Implementation of effective screening paradigms to expedite project progression and IND candidate nomination
• Close collaboration with the in vivo pharmacology, immunology, and translational biology teams to achieve project milestones

Qualifications:

• Ph.D. degree in virology or molecular biology with at least 4 years of post-degree research experience
• Demonstrated expertise in genomics and/or molecular biology essential. Previous experience in some aspect of virology is highly desirable
• Experience working with large scale structural and functional genomic datasets is highly desirable
• Strong organizational skills and the ability to work effectively within a team environment is essential

Benefits and Perks:

• Oncorus, Inc. is an Equal Opportunity Employer, and offers a comprehensive benefits package including health, dental, life insurance, 401k, unlimited vacation and much more.
• Salary: commensurate with role and experience

Oncorus is an EEO employer committed to an exciting, diverse, and enriching work environment.

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