Director, Cancer Biology

My client is expanding and seeks a Director to take on the following tasks:

* Provide direction and leadership to a team of cancer biologists focused on expanding the DNA Damage Response platform

* Develop the overall strategy for deploying the DDR platform to advance the drug discovery pipeline

* Lead a team of scientists in the design, development, and implementation of robust enzyme- and cell-based assays to characterize the effects of lead compounds on DDR pathways

* Oversee the generation and analysis of high-quality experimental data to identify and confirm the mechanism of action of lead compounds

* Guide new DDR target identification and validation activities, including CRISPR-based synthetic lethal screens, both internally and through external service providers

* Collect, analyze, and summarize data for presentations, reports, publications, and patents

* Interact cross-functionally and provide scientific leadership on preclinical project teams

* Maintain an up-to-date understanding of new technologies and relevant scientific advances in cancer and DDR biology from literature, scientific meetings, and professional network

The ideal candidate will possess the following qualities:

* PhD and extensive experience in DDR biology and small molecule drug discovery

* Hands-on experience with enzyme- and cell-based assays typically used to study DDR biology, DNA repair, and replication stress

* Knowledge of the current therapeutic landscape and target opportunities in the DDR space

* Demonstrated ability to mentor and manage team of cancer biologists

* Experience performing and interpreting CRISPR-based synthetic lethal screens

* Experience managing external scientific collaborations