Senior Research Associate (Cellular and Molecular Biology

Cambridge, Massachusetts, US
Jun 14, 2021
Jun 16, 2021
Employment Type
Full time
Salary Type
Senior Research Associate (Cellular and Molecular Biology)

Our culture is entrepreneurial, inclusive and caring. We're passionate about our work. And we embrace a pioneering spirit. Join us as we strive to develop innovative therapies with the power to give people with genetic diseases freedom for life.

Senior Research Associate (Cellular and Molecular Biology)

We are looking for a Senior Research Associate who is passionate about their profession and inspired by being part of team, working in life sciences, to bring a therapy to patients. This is an opportunity to make an impact while being part of a historically significant company that is making a difference to the lives of millions of people.

As a Senior Research Associate in AVROBIO's R&D they will join the Gene Therapy & Biology department. This is a fast-paced science-driven team dedicated to discovery and exploratory analyses in both the preclinical and the clinical space. Under the supervision of a Scientist/Senior Scientist, they will gain hands-on experience on state-of-the-art analytics and cutting-edge cellular, molecular and biochemical technologies to move our research from the bench to bedside and back.


Research and Development

May 28 2021

Key Responsibilities
  • Isolation, culture and lentiviral transduction of primary cells using aseptic techniques.
  • Perform cellular and molecular assays (e.g. flow cytometry, cell sorting, PCR, qPCR, ddPCR, LAM-PCR, western blot).
  • Generate molecular libraries for RNA-seq, scRNA-seq, ATAC-Seq, CITE-seq and other high throughput techniques and run Illumina sequencing.
  • Perform exploratory analyses on biological samples from patients enrolled in AVROBIO's clinical trials using immunophenotyping, molecular and single cell sequencing assays.
  • Support animal experiments locally and at CROs.
  • Potentially support the R&D team cross-functionally, i.e. other programs and assist in the training of new technical staff.
  • Maintain an electronic laboratory notebook that provides clear documentation of experimental methods and results.
  • Work with the laboratory manager to maintain equipment and supplies.
Minimum Requirements/ Qualifications
  • BS or MS degree with 3+ years of laboratory experience (industry experience will be considered a plus).
  • Solid base of cell culture and aseptic techniques (experience with human primary cells will be considered a plus).
  • Extensive experience with multicolor flow cytometry (experience with FACS cell sorters will be considered a plus).
  • Extensive experience with molecular biology techniques including DNA/RNA isolation, cloning, PCR and RT-PCR (experience with library preparation for high-throughput sequencing will be considered a plus).
  • Experience with mouse work preferred, but not required.
  • Ability to troubleshoot and optimize protocols with the assistance of a supervisor.
  • Ability to quickly learn new techniques and adapt to a fast pace environment.
  • Must demonstrate careful attention to detail alongside excellent organizational, time management, and communication skills.
  • Must enjoy working as part of a cross-functional team and have interest in the field of gene therapy.

Our vision is to bring personalized gene therapy to the world. We aim to prevent, halt or reverse disease throughout the body with a single dose of gene therapy designed to drive durable expression of functional protein, even in hard-to-reach tissues and organs including the brain, muscle and bone. Our ex vivo lentiviral gene therapy pipeline includes clinical programs in Fabry disease, Gaucher disease type 1 and cystinosis, as well as preclinical programs in Hunter syndrome, Gaucher disease type 3 and Pompe disease. AVROBIO is powered by our industry leading plato® gene therapy platform, our foundation designed to deliver gene therapy worldwide. We are headquartered in Cambridge, Mass., with an office in Toronto, Ontario.