Research Scientist, RNA Biology

Employer
GenScript
Location
Seattle, Washington, US
Salary
Competitive
Posted
Jun 10, 2021
Closes
Jun 11, 2021
Ref
2241955212
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
We are seeking a motivated research scientist to join our interdisciplinary R&D team with the focus on product development of therapeutic nucleic acids. This candidate will help within the R&D group to develop new products and applications. He/she will also work with our production team for technology transfer.

?Key Responsibilities:

* Contribute in R&D projects with focus in gene and RNA therapeutics applications
* Synthesis and characterization of RNA and DNA constructs
* Help to develop and optimize large scale DNA and RNA production process
* Help to define, write and transfer standard operating procedures to the production teams
* Help to define QC methods for the developed products/service
* Collaborate with and/or supervise the scientists and engineers on joint projects
* Perform statistical data analysis and present the results

Qualifications:

* MSc in Biochemistry, Molecular Biology, Synthetic Biology, Microbiology, Biomedical Engineering, or related biomedical field. BSc with a minimum of 3 year experience in the pharmaceutical company, biotech or related industries
* Proven ability to analyze multi-factorial data, provide conclusions and design next steps independently.
* Knowledgeable in nucleic acid chemistry, molecular/cellular mRNA metabolism and translation mechanism
* Understand RNA biology and RNA chemistry including structure simulation, design, modification and stability improvement
* Good molecular biology laboratory skills. Experience in nucleic acid amplification,in vitro transcription, primer/probe/vector design, enzymatic reactions, PCR, qPCR, next-generation sequencing, molecular cloning and large scale plasmid preparation
* Experience in process development for cGMP-compliant therapeutic nucleic acid production is a plus
* Experience in various qualification, quantification, and nucleic acid purification methods, e.g., PAGE, CE, HPLC, UPLC, NGS, etc, is preferred
* Ability to effectively collaborate in a dynamic, fast-paced, and cross-functional matrix environment
* Good documentation practices. Able to prepare documents including data summaries, technical, analytical, and scientific reports, and transfer the procedures to manufacturing
* Self-motivated and passionate. Comfortable to work in a fast-paced work environment

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