Research Scientist, RNA Biology

Seattle, Washington, US
Jun 10, 2021
Jun 11, 2021
Employment Type
Full time
Salary Type
We are seeking a motivated research scientist to join our interdisciplinary R&D team with the focus on product development of therapeutic nucleic acids. This candidate will help within the R&D group to develop new products and applications. He/she will also work with our production team for technology transfer.

?Key Responsibilities:

* Contribute in R&D projects with focus in gene and RNA therapeutics applications
* Synthesis and characterization of RNA and DNA constructs
* Help to develop and optimize large scale DNA and RNA production process
* Help to define, write and transfer standard operating procedures to the production teams
* Help to define QC methods for the developed products/service
* Collaborate with and/or supervise the scientists and engineers on joint projects
* Perform statistical data analysis and present the results


* MSc in Biochemistry, Molecular Biology, Synthetic Biology, Microbiology, Biomedical Engineering, or related biomedical field. BSc with a minimum of 3 year experience in the pharmaceutical company, biotech or related industries
* Proven ability to analyze multi-factorial data, provide conclusions and design next steps independently.
* Knowledgeable in nucleic acid chemistry, molecular/cellular mRNA metabolism and translation mechanism
* Understand RNA biology and RNA chemistry including structure simulation, design, modification and stability improvement
* Good molecular biology laboratory skills. Experience in nucleic acid amplification,in vitro transcription, primer/probe/vector design, enzymatic reactions, PCR, qPCR, next-generation sequencing, molecular cloning and large scale plasmid preparation
* Experience in process development for cGMP-compliant therapeutic nucleic acid production is a plus
* Experience in various qualification, quantification, and nucleic acid purification methods, e.g., PAGE, CE, HPLC, UPLC, NGS, etc, is preferred
* Ability to effectively collaborate in a dynamic, fast-paced, and cross-functional matrix environment
* Good documentation practices. Able to prepare documents including data summaries, technical, analytical, and scientific reports, and transfer the procedures to manufacturing
* Self-motivated and passionate. Comfortable to work in a fast-paced work environment

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