Director, Cancer Biology

Employer
Affinity Executive Search
Location
Waltham, Massachusetts, US
Salary
Competitive
Posted
Jun 08, 2021
Closes
Jun 12, 2021
Ref
1997671023
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
My client is expanding and seeks a Director to take on the following tasks:

* Provide direction and leadership to a team of cancer biologists focused on expanding the DNA Damage Response platform

* Develop the overall strategy for deploying the DDR platform to advance the drug discovery pipeline

* Lead a team of scientists in the design, development, and implementation of robust enzyme- and cell-based assays to characterize the effects of lead compounds on DDR pathways

* Oversee the generation and analysis of high-quality experimental data to identify and confirm the mechanism of action of lead compounds

* Guide new DDR target identification and validation activities, including CRISPR-based synthetic lethal screens, both internally and through external service providers

* Collect, analyze, and summarize data for presentations, reports, publications, and patents

* Interact cross-functionally and provide scientific leadership on preclinical project teams

* Maintain an up-to-date understanding of new technologies and relevant scientific advances in cancer and DDR biology from literature, scientific meetings, and professional network

The ideal candidate will possess the following qualities:

* PhD and extensive experience in DDR biology and small molecule drug discovery

* Hands-on experience with enzyme- and cell-based assays typically used to study DDR biology, DNA repair, and replication stress

* Knowledge of the current therapeutic landscape and target opportunities in the DDR space

* Demonstrated ability to mentor and manage team of cancer biologists

* Experience performing and interpreting CRISPR-based synthetic lethal screens

* Experience managing external scientific collaborations

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