BS-MS Molecular Biologist

Job Description Summary:

The BS-MS Molecular Biologist is responsible for performing scientific experiments that contribute to research and drug discovery activities at PTC. This position assists in the conduct of early stage research, the goal of which is the identification of New Chemical Entities (NCEs), as well as the advancement of research programs from the identification of screening hits to advanced lead optimization. The incumbent is also responsible for communicating experimental results to his/her supervisor and the project team.
The BS-MS Molecular Biologist supports adherence to all regulatory requirements and company Standard Operating Procedures (SOPs) including as appropriate.

Job Description:

Primary duties/responsibilities:

• Under limited supervision, executes experiments as directed by the supervisor and communicates results as part of multi-disciplinary team(s).
  

• Applies relevant scientific principles and techniques to research problems.
  

• Maintains detailed laboratory notebooks.
  

• Maintains broad knowledge of state-of-the-art principles and techniques and may contribute to the identification of new project areas or technologies.
  

• Presents findings internally and contributes to the publication of the work of the project team in well-established and peer reviewed journals, subject to internal scientific and legal approval.
  

• May provide technical and scientific input to the project team or research leadership
  

• Contributes to the development of patent applications as appropriate.
  

• Complies with all safety requirements.
  

• Contributes to general lab operations such as:
  
  • Equipment maintenance.
    
  • Identification of capital equipment needs
    
  • Maintenance of clean and uncluttered work areas
    
  • Maintain inventory and ordering lab supplies as needed.
    

Specific duties may also include, but may not be limited to, the following:

• Provides support for high throughput screening including the design of primary assays, the goal of which is the identification of additional hits and new chemical scaffolds.
  

• Provides support for lead optimization by screening compounds and/or supporting structure activity relationship (SAR) studies involving the characterization of the biological activity of compounds in various assays. Profiles selected compounds in additional cells/assays.
  

• Conducts mechanism of drug activity studies.
  

KNOWLEDGE/SKILLS/ABILITIES REQUIRED

• Hands-on experience with mammalian cell culture.
  
• Experience in running cell-based assays.
  
• Experience using standard cell and molecular biology techniques including molecular cloning, SDS PAGE, western blot, ELISA/Mesoscale Discovery (MSD), nucleic acid isolation, purification and quantification, PCR, qRT-PCR.
  

* Minimum level of education and years of relevant work experience.

• Bachelor's degree in a scientific discipline , preferably Molecular Biology or Biochemistry with a minimum of 4 years' experience, OR, Master's degree in a scientific discipline with a minimum of 1 years of relevant experience.
  

* Special knowledge or skills needed and/or licenses or certificates required.

• Demonstrates technical proficiency, scientific creativity, and the ability to collaborate with others on cross functional teams in a fast-paced, matrixed, environment consisting of internal and external team members.
  
• Possesses knowledge of scientific principles and concepts and keeps current with relevant scientific literature.
  
• Proficiency with Microsoft Office- preferably MS Excel and MS PowerPoint.
  
• .Effective verbal and written communication and skills.
  
• Analytical thinker with problem-solving skills and the ability to adapt to changing priorities and deadlines.
  
• Effective planning, organization and time management skills including the ability to support and prioritize multiple projects.
  

*Special knowledge or skills and/or licenses or certificates preferred.

• Experience performing transient and stable DNA/RNA transfection, Lentiviral transduction, isolation of stable clones, cryopreservation, RNAi or CRISPR and cytotoxicity assays is desired.
  
• Experience in compound screening in 96-well or 384-well format is desired.
  
• ​Experience with laboratory automation and robotic plate handlers (JANUS, PlateMate Plus) is desired.
  
• Experience with protein overexpression and purification is desired.Experience with Immunofluorescence microscopy is desired.
  

· Experience with mRNA expression profiling, ribosome profiling and/or CRISPR-CAS gene editing is desired.

EEO Statement:

PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.

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