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Senior Research Associate, Molecular Biology & Genomics

Homology Medicines, Inc.
Bedford, Massachusetts, US
Closing date
Sep 9, 2021
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The Senior Research Associate, Molecular Biology & Genomics, is a key member of our Molecular Genomics team, developing advanced genomics technologies to identify and advance rare disease targets for drug discovery and for development. This role is responsible for utilizing a variety of techniques including but not limited to advanced cloning, nucleic acid purification, PCR-based assays, mammalian cell culture, viral preparation and purification, and NGS, to support the Genomics team in executing DNA-based therapy workflow. This organized, self-motivated, detail-oriented, and team-oriented researcher will partner with co-workers, senior experts, and across multiple functions including Discovery Research and Analytical Process Development, to ensure work is completed to support Genomics research.

  • Design and implement experiments, analyze data, and present results to demonstrate feasibility of new methods with the goal of efficiently moving products through our pipeline.
  • Analysis and interpretation of genome-scale data.
  • NGS
  • Advanced cloning, PCR-based assays, and qPCR.
  • Column and solvent-based nucleic acid purification.
  • Mammalian Cell Culture and cell-based assays.
  • Molecular genomic assays evaluating genome-wide editing.
  • DNA/RNA extraction and quantification.
  • Vector design and cloning.
  • Whole-genome viral integration analysis.
  • Gene expression.
  • Expression Cassette design.
  • Maintain expertise in state-of-the-art molecular biology tools and methods.

  • BS or MS degree in Biological Sciences with a minimum of 5 years' relevant, hands-on experience in an academic or biotechnology/pharmaceutical laboratory environment.
  • Organized, self-motivated, detail-oriented, and team-oriented.
  • Demonstrated excellence in communication, organizational, and interpersonal skills are essential.
  • Demonstrated ability to think critically, problem-solve creatively, and to work collaboratively as a member of our fast-paced research team required, and must be able to accommodate rapidly changing priorities and deadlines.
  • Familiarity with robotic liquid handlers, experience with Fluidics and Flow Cytometry, and/or experience with single-cell genomics and Bioengineering a plus.
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