Scientist, Computational Biology
- Employer
- CRISPR Therapeutics
- Location
- Cambridge, Massachusetts, US
- Salary
- Competitive
- Closing date
- Jun 12, 2021
View more
- Sector
- Academic / Research
- Field
- Informatics / GIS
- Discipline
- Energy, Biology
- Salary Type
- Salary
- Employment Type
- Full time
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Company Overview
At CRISPR Therapeutics, we are focused on developing transformative gene-based medicines for serious human diseases. We are rapidly translating our specific, efficient, and versatile CRISPR/Cas9 gene-editing platform into therapies to treat hemoglobinopathies, cancer, diabetes, and other diseases. Our multi-disciplinary team of world-class researchers and drug developers works every day to translate our CRISPR/Cas9 technology into breakthrough human therapeutics. Our lead program targeting the blood diseases β-thalassemia and sickle cell disease has entered clinical testing, and our immuno-oncology programs, focused on CRISPR/Cas9-edited allogeneic CAR-T cell therapies, have the potential to deliver a new generation of cancer therapies to patients.
Job Summary
We are seeking a talented Computational Biologist/Bioinformatics Scientist to tackle challenging biological problems and work collaboratively with research groups to build the tools, algorithms, and pipelines required to support the development of transformative CRISPR/Cas9-based gene editing therapies.
Responsibilities
Minimum Qualifications
Preferred Qualifications
CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.
To view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy
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At CRISPR Therapeutics, we are focused on developing transformative gene-based medicines for serious human diseases. We are rapidly translating our specific, efficient, and versatile CRISPR/Cas9 gene-editing platform into therapies to treat hemoglobinopathies, cancer, diabetes, and other diseases. Our multi-disciplinary team of world-class researchers and drug developers works every day to translate our CRISPR/Cas9 technology into breakthrough human therapeutics. Our lead program targeting the blood diseases β-thalassemia and sickle cell disease has entered clinical testing, and our immuno-oncology programs, focused on CRISPR/Cas9-edited allogeneic CAR-T cell therapies, have the potential to deliver a new generation of cancer therapies to patients.
Job Summary
We are seeking a talented Computational Biologist/Bioinformatics Scientist to tackle challenging biological problems and work collaboratively with research groups to build the tools, algorithms, and pipelines required to support the development of transformative CRISPR/Cas9-based gene editing therapies.
Responsibilities
- Develop and implement computational biology tools and software to support gene editing and research activities
- Generate and test hypotheses on genome-scale data using analytical and statistical methods
- Work in close collaboration with cell/molecular biologists; contribute to the collaboration by performing computational analyses to inform experimental design, answer biological questions, and guide decision-making for therapeutic programs
- Balance integration and extension of existing bioinformatics and next-generation sequencing (NGS) tools with the creation of new tools and algorithms as needed for various projects
- Author research and regulatory reports to support IND and BLA filings
Minimum Qualifications
- Ph.D. degree in quantitative or basic science (computational biology, bioinformatics, computer science, chemistry, physics, mathematics, or applied science preferred); M.S. graduates with exceptional track record and 6+ years of relevant work experience will also be considered
- Demonstrated record of developing computational pipelines to analyze bulk and/or single-cell sequencing data (e.g. DNA-seq, RNA-seq, ATAC-seq)
- Experience creating biological interpretation of NGS analyses and putting results into the context of diseases such as oncology and its related sequencing databases (TCGA, CCLE, etc.)
- Proficiency with Python is essential; familiarity with other languages such as C++, R, and MATLAB is also helpful
- Ability to work independently and successfully in a matrix environment, prioritize and manage multiple tasks simultaneously, integrate cross-functional issues and balance competing priorities effectively
- A high degree of energy, accuracy and attention to detail, and a passion for creating transformative gene-based medicines for patients with serious diseases
Preferred Qualifications
- 2+ years of relevant work experience in biotech or pharmaceutical setting
- Demonstrated record of authoring research and regulatory reports to support IND and BLA filings
- Experience analyzing gene-editing data (on-target, off-target, translocation)
- Familiarity with sequencing platforms (Illumina, 10x Genomics) and NGS library preparation methods
- Proficiency with statistical and/or machine learning methods
- Proficiency with handling large-scale genomic data in a Linux and/or cloud environment (e.g. AWS, DNAnexus)
CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.
To view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy
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