PhD Scientist, Biology (NRD)

3 days left

Employer
PTC Therapeutics, Inc.
Location
South Plainfield, New Jersey, US
Salary
Competitive
Posted
Jun 04, 2021
Closes
Jun 15, 2021
Ref
2196106544
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
Job Description Summary:

The PhD Scientist, Biology (NRD) is responsible for planning and performing scientific experiments that contribute to PTC's research and drug discovery activities. The incumbent works cross-functionally with internal departments, and external resources as appropriate, as part of PTC's discovery science project teams.
The PhD Scientist, Biology (NRD) supports adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.

Job Description:

Primary duties/responsibilities:
  • With guidance from the advisor plans, initiates, directs and executes scientific research and experiments and interprets and communicates results as part of multi-disciplinary team(s). This includes performing analyses of primary research literature.
  • Presents findings internally to cross-functional teams.
  • May Participate in the development and writing of patent applications.
  • Abides by all safety and regulatory guidelines.
  • Maintains a detailed laboratory notebook.
  • Performs other tasks as assigned.
  • Interviews and contributes to the evaluation of candidates.
  • May provide scientific advice to research leadership on projects and areas of expertise.
  • Abides by all safety requirements.
  • Contributes to general lab needs such as:
    • Equipment maintenance.
    • Capital equipment purchases.
    • Troubleshoot


KNOWLEDGE/SKILLS/ABILITIES REQUIRED
  • Extensive experience with eukaryotic cell culture.
  • Hands on experience with animal tissue work.
  • Experience in nucleic acid, isolation, quantification.
  • Experience in protein quantification end analysis methods such as Western blot, ELISA, MSD, HTRF, and other high throughput assays (multiple assay platforms).
  • Experience in High throughput assay (HTS) development and implementation


* Minimum level of education and years of relevant work experience.
  • Ph.D. in a scientific discipline preferably Molecular Biology or Biochemistry or related with a minimum of 1 years' post-doctoral or Industry experience. Fresh PhD graduates welcome to apply.


* Special knowledge or skills needed and/or licenses or certificates required.
  • Demonstrate ability to work on complex problems to produce experimental data across one or more projects.
  • Exercises independent judgement within defined procedures and practices.
  • Demonstrates technical proficiency, collaboration with others within a fast-paced, matrixed, team environment consisting of internal and external team members.
  • Possesses detailed and expert knowledge of scientific principles and concepts.
  • Demonstrate ability to work effectively in a multi-disciplinary team environment.
  • Proficiency with Microsoft Office preferably MS Excel and MS PowerPoint or similar.
  • Excellent verbal and written communication and skills.
  • Analytical thinker with excellent problem-solving skills.
  • Demonstrates an understanding of the strategic alignment of his/her work with corporate goal(s) and demonstrates the ability to adapt to changing priorities and deadlines.
  • Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.


*Special knowledge or skills and/or licenses or certificates preferred.
  • Experience designing and conducting in vitro and vivo studies of compound activity on splicing and protein modulation.
  • Experience designing and conducting high-throughput screening studies of compound activity; Evaluate lead compounds in multiple cell-based assays as well as an understand the different drug discovery/development stages.
  • Experience designing and conducting cell-based studies of compound activity on pre-mRNA splicing as well as mechanism of action studies; Develop novel assays to demonstrate compound mechanism of action for nucleotide repeat diseases or other disease-relevant platforms.
  • Experience in working with neuronal cells; Isolate and maintain primary neuronal cultures, including differentiated iPSCs


* Travel requirements

Up to 10%

EEO Statement:

PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.

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