Associate Director, Pluripotent Stem Cell Biology

3 days left

Employer
ElevateBio
Location
Waltham, Massachusetts, US
Salary
Competitive
Posted
Jun 04, 2021
Closes
Jun 26, 2021
Ref
2054541558
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
Title: Associate Director, Pluripotent Stem Cell Biology

Location: Waltham, MA

Reports to: Director, Regenerative Medicine

The Role:

ElevateBio is actively recruiting an Associate Director, Pluripotent Stem Cell Biology. This individual will report to the Director, Regenerative Medicine and will possess excellent scientific/technical skills. This person will lead an R&D team focused on establishing hypoimmunogenic iPSC lines for the development of iPSC-derived cell therapies.

Responsibilities:
  • Lead a team focused on the development and characterization of hypoimmunogenic iPSCs
  • Contribute to strategy for generating hypoimmunogenic iPSCs
  • Collaborate with editing team to generate genetically modified iPSC lines
  • Design and oversee the execution of in vitro and in vivo immunogenicity studies to characterize the interaction between immune system and iPSCs/derivatives
  • Manage CROs for outsourced in vivo research activities, including study design, monitoring, and data analysis
  • Interact closely with project teams and represent Regenerative Medicine group in cross-functional team forums
  • Communicate program progress and issues to senior management, to regulatory agencies as necessary, and at national and international conferences as appropriate


Requirements:
  • PhD with 8+ years of relevant experience in pluripotent stem cells and/or transplant immunology
  • 5+ years of industry experience leading teams of at least 3 scientists
  • Expertise in transplant immunology and immune-evasion strategies for allogeneic cell therapies
  • Experience with in-vitro immunology workflows including cytotoxicity assays, cytokine profiling, proliferation assays, flow cytometry, ELISA and ELISpot
  • Strong knowledge of in vivo immunogenicity assessment employing syngeneic and allogeneic hosts
  • Demonstrated experience in stem cell biology including reprogramming, iPSC characterization and differentiation
  • Experience with humanized mouse models and managing a CRO
  • Experience with gene editing is a plus
  • Highly adaptable and responsive, and committed to completing tasks in a timely fashion
  • Demonstrated ability to work in a dynamic environment as a team player with a strong work ethic
  • Excellent team player with good interpersonal and communication skills
  • Excellent oral and written communication skills, including supporting documentation in laboratory notebooks and study reports for regulatory filing activities


Why join ElevateBio?

ElevateBio is accelerating the future of biotechnology; developing the next-generation of cell, viral and regenerative medicine therapeutics for the treatment of severe diseases. We have launched a revolutionary new model that integrates innovators, infrastructure and capital to effectively develop cell, gene and related therapies for patients with severe and life-threatening disorders. With plans for a cutting-edge laboratory and manufacturing center already underway, we're building a world-class organization lead by expert talent with bench-to-bedside capabilities.

At the heart of the ElevateBio platform is ElevateBio Base Camp, a state-of-the-art research, development and manufacturing center for innovation in the Greater Boston Area to be staffed with a world-class team of scientists.

Our Vision:
Next-generation product development for advanced therapies supported by global bench-to-bedside expertise shared across our portfolio of companies

ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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