Principal Scientist, Biology

Aclaris Therapeutics
St. Louis, Missouri, US
Jun 04, 2021
Jul 09, 2021
Biology, Grant Writing
Employment Type
Full time
Salary Type
Position Summary:

The Principal Scientist, Biology is an independent drug discovery scientist who focuses on the design and execution of projects in their area of expertise. This position will utilize training in biological, immunological, or other pharmacological analysis in the context of drug discovery. In this position, you will drive focused internal and contract drug discovery and biological research as part of a team of scientists, addressing complex scientific questions in a fluid team environment. Efficient and effective execution is critical.

Essential Duties and Responsibilities:

This position will specialize in Cell Biology, Immunology and/or Pharmacology. Essential roles, responsibilities, and activities a candidate may expect to assume in this position are listed below:
  • Technology and/or project leadership for internal and/or external projects
  • Strategy, planning and execution of biologic research studies
  • Independently develop and validate assays and models including automation and execution
  • Effective data analysis, interpretation, and impact planning
  • Quantitative and qualitative analysis
  • Development of project plans and effective participation in SOW generation and execution
  • Coordinate equipment and supply needs/purchases
  • Grant writing, manuscript preparation and external presentation
  • Presentations and report writing both internal and with customers and other stake holders

Other Duties:

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

Physical Demands:

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

While performing the duties of this job, the employee is occasionally required to stand, walk, use hands to handle, feel or operate objects, tools or controls; and reach with hands and arms. The employee is occasionally required to sit; climb or balance; stoop, kneel, crouch or crawl; talk or hear.

The employee must occasionally lift and/or move objects up to 10 pounds. Specific vision abilities required by this job include close vision, distance vision, color vision, peripheral vision, depth perception and the ability to adjust focus.

Required Education and Experience:
  • Ph.D. with 2+ years' experience or B.S./M.S. scientist with 8+ years relevant drug discovery experience

Required Knowledge, Skills, Abilities & Behaviors:
  • Deep understanding of basic cell biology and immunology with demonstrated expertise in cell and tissue culture techniques, including mammalian cell
  • Preferred cell biology skills include PCR, gene knock-in and knock-out, siRNA, shRNA, CRISPR, flow cytometry.
  • Preferred pharmacology skills include, rodent dosing, pharmacodynamic and animal model execution, tissue and blood harvesting
  • Ability to independently design, develop and execute new approaches and effectively apply traditional approaches to drug design and biological analysis
  • Viewed as an emerging expert in field of study
  • Work across lines, interface effectively with project teams, chemistry leadership, company management and customers
  • Effectively communicate complex data and concepts to the broader organization
  • Expertise in FACS desired
  • Experience with Immune cell isolation, activation and molecular and phenotypic responses
  • Ability to effectively function in a fast paced, challenging, multidisciplinary team environment

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