Data Scientist - Computational Biology

United Therapeutics
Silver Spring, Maryland, US
Jun 03, 2021
Aug 12, 2021
Biology, Modeling
Employment Type
Full time
Salary Type
The Job Details are as follows:
What we do
United Therapeutics Corporation focuses on the strength of a balanced, value-creating biotechnology model. We are confident in our future thanks to our fundamental attributes, namely our commitment to quality and innovation, the power of our brands, our entrepreneurial culture and our bioinformatics leadership. We also believe that our determination to be responsible citizens - having a positive impact on patients, the environment and society - will sustain our success in the long term.
We currently have five approved products on the market and a long-term mission of providing an unlimited supply of transplantable organs for those who need them.
Our company was founded by an entrepreneur whose daughter was diagnosed with a life-threatening condition. She sought to find treatment options and a cure for her daughter and patients like her. We are founder-led, and relentless in our pursuit of "medicines for life". We continue to research and develop treatments for cardiovascular and pulmonary diseases, pediatric cancers and other orphan diseases.
How you'll contribute
The Computational Lab for In Silico Molecular Biology (CLIMB) applies computational modeling to enable in silico design and testing of therapies for lung disease. As part of this effort to develop an integrative multi-scale lung model, the Data Scientist - Computational Biology will analyze and integrate diverse data types, including molecular, imaging, and text-based (scientific publications) to map biological processes relevant to lung disease pathogenesis and treatment.
- Analyze and interpret high-dimensional molecular datasets, both public and internal, to identify biological processes/pathways relevant to lung physiology and pathology and apply this information to discover drug targets and infer mechanism of action.
- Conduct research into suitable machine learning approaches for deriving insights from molecular datasets through gene regulatory network inference, dimensionality reduction, clustering, or supervised learning.
- Apply natural language processing techniques to extract relationships among biological processes from literature sources.
- Integrate biological knowledge from diverse sources, such as pathway databases, protein interaction networks, ontologies, and functional assays, to enhance interpretation of molecular datasets.
- Communicate results effectively through interactive visualizations, presentations at internal and external meetings, and peer-reviewed publications.
- Perform other duties as assigned.
For this role you will need
Minimum Qualifications
- Bachelor's degree in computational biology, applied mathematics or related field of study
- 6+ years of industry experience with a BA/BS
- 4+ years of industry experience with a MA/MS
- 2+ years of industry experience with a PhD
- Expertise in statistical and machine learning methods applied to high-dimensional molecular datasets, text mining, and/or imaging data
- Fluency in one or more scientific programming languages (e.g. Python, R, Julia, and/or MATLAB)
- Ability to communicate effectively with both technical and non-technical audiences as demonstrated by record of presentations and publications
Preferred Qualifications
- Master's degree in computational biology, applied mathematics or related field of study
- Doctor of Philosophy (PhD) in computational biology, applied mathematics or related field of study
- 1+ year experience with common databases and tools relevant to bioinformatics and systems biology
- 1+ year experience with imaging (CT, MRI) data
- Knowledge of molecular/cellular biology, pulmonary, physiology, and drug development
- Strong data visualization skills, including interactive visualization (e.g. R Shiny or d3.js)
- Proficiency with deep learning software packages
Life as a Unitherian
At United Therapeutics, you'll realize quickly that it is not an ordinary place to work! When you join our company, you will learn, grow, contribute, have fun, and be challenged... all while making a difference in the lives of our patients.
United Therapeutics Corporation is an Equal Opportunity/Affirmative Action Employer - EOE Minorities / Females / Protected Veterans / Individuals with Disabilities
We strive to be an organization that engages the minds, hearts, and most spirited efforts of each of our employees. Our sense of purpose transforms what we do from work into mission, occupation into vocation and achievement into success.
We challenge our employees with innovative and revolutionary projects, offer an environment which fosters high-level job performance and provide a highly competitive total rewards package. This is what makes United Therapeutics a stimulating place to work.