In Vivo Pharmacology & Biomarker Lead, Biology

Employer
ENANTA Pharmaceuticals, Inc. Enanta Pharmaceuticals
Location
Rockville, Maryland, US
Salary
Competitive
Posted
May 16, 2021
Closes
May 19, 2021
Ref
2180521975
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
National Postdoctoral Association Career Center

Job Summary:

Reporting the Head of Biology, the In Vivo Pharmacology and Biomarker Lead will oversee in vivo pharmacology studies performed in Enanta's Biology group in support of multiple small molecule discovery programs in Liver Disease and Virology. The Principal Scientist will be expected to work closely with a cross-functional team to deliver comprehensive in vivo data packages for small molecule drug candidates, including mechanism of action, PK/PD, and efficacy studies.

Primary Responsibilities:

  • Provide scientific leadership for the design, execution, and data analysis for in vivo pharmacology studies at Enanta.
  • Accountable for identifying, developing, and implementing new in vivo models to support Enanta's portfolio needs via internal and external means.
  • Manage a small team of internal scientists and develop close working relationships with a network of CROs and academic labs to deliver high-quality in vivo pharmacology data. Perform diligence on external collaborators to ensure the quality and best practices.
  • Support the identification, preclinical validation, and clinical deployment of target engagement and mechanistic biomarkers.
  • Provide leadership and hands-on mentoring to further develop Enanta's internal in vivo capability.
  • Develop comprehensive study protocols for peer review and work in a collaborative manner to conduct in vivo studies.
  • Independently communicate results to cross-functional project teams and update senior management on overall project strategy and goals.
  • Prepare study reports for both internal discussions with stakeholders and regulatory submissions.
  • Generate and be accountable for the necessary Animal Use Protocols that ensures Biology team members comply with all regulatory requirements and internal policies. Actively participate in Enanta's Institutional Animal Care and Use Committee.
  • Build Enanta's external reputation through scientific publications and presentations at relevant conferences.

Requirements

Job Summary:

Reporting the Head of Biology, the In Vivo Pharmacology and Biomarker Lead will oversee in vivo pharmacology studies performed in Enanta's Biology group in support of multiple small molecule discovery programs in Liver Disease and Virology. The Principal Scientist will be expected to work closely with a cross-functional team to deliver comprehensive in vivo data packages for small molecule drug candidates, including mechanism of action, PK/PD, and efficacy studies.

Primary Responsibilities:

  • Provide scientific leadership for the design, execution, and data analysis for in vivo pharmacology studies at Enanta.
  • Accountable for identifying, developing, and implementing new in vivo models to support Enanta's portfolio needs via internal and external means.
  • Manage a small team of internal scientists and develop close working relationships with a network of CROs and academic labs to deliver high-quality in vivo pharmacology data. Perform diligence on external collaborators to ensure the quality and best practices.
  • Support the identification, preclinical validation, and clinical deployment of target engagement and mechanistic biomarkers.
  • Provide leadership and hands-on mentoring to further develop Enanta's internal in vivo capability.
  • Develop comprehensive study protocols for peer review and work in a collaborative manner to conduct in vivo studies.
  • Independently communicate results to cross-functional project teams and update senior management on overall project strategy and goals.
  • Prepare study reports for both internal discussions with stakeholders and regulatory submissions.
  • Generate and be accountable for the necessary Animal Use Protocols that ensures Biology team members comply with all regulatory requirements and internal policies. Actively participate in Enanta's Institutional Animal Care and Use Committee.
  • Build Enanta's external reputation through scientific publications and presentations at relevant conferences.

Job Information
  • Job ID: 54040871
  • Location:
    Watertown, Massachusetts, United States
  • Company Name: ENANTA Pharmaceuticals, Inc.
  • Job Function: Biology
  • Job Type: Full-Time
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Enanta Pharmaceuticals is using its robust, chemistry-driven approach and drug discovery capabilities to become a leader in the discovery and development of small molecule drugs for the treatment of viral infections and liver diseases. Two protease inhibitors, glecaprevir and paritaprevir, discovered and developed through Enanta's collaboration with AbbVie, have now been approved around the world as part of AbbVie's regimens for the treatment of hepatitis C virus (HCV) infection. The leading regimen is sold under the tradena...

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