Associate Director, Molecular and Target Biology

Employer
AnaptysBio, Inc.
Location
San Diego, California, US
Salary
Competitive
Posted
May 09, 2021
Closes
May 11, 2021
Ref
2172137794
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
Position Summary

The candidate will play a lead role in Molecular Biology and Target Biology, with responsibilities to include the supervision of technology development to support target validation and therapeutic antibody discovery. Additional responsibilities may include new target identification, multiomics data analysis, mechanism of action studies, and project leadership. Both within the Molecular Biology research group and within interdisciplinary project groups, the candidate will provide technical and scientific oversight to solve challenging problems and accelerate project timelines.

Essential Functions

Play a leadership role in protein engineering, antibody screening technologies, therapeutic antibody optimization, and new target validation.
Design and implementation of cell-based assays to validate new targets.
Multiomics data analysis of targets from public and in-house datasets.
Protein design and engineering for target expression in mammalian cells.
Design of experiments to evaluate biophysical interactions between targets and relevant ligands.
Design and implementation of optimized antibody screening strategies from human and mouse single B cells.
Design of natural and synthetic antibody libraries for mammalian cell and phage display.
Optimization of phage display and mammalian cell display antibody discovery and selection strategies.
Design, creation and implementation of new cloning strategies using different cloning methods, PCR techniques and primer design.
Design, creation and construction of mammalian display vectors for AnaptysBio libraries and optimize transfection methods (electroporation, lentiviral vectors, etc.).
Design, optimization and implementation of RT-PCR from single cells and tissues.
Analyze sequence activity relationships to enable affinity maturation of antibodies.
Analyze RNAseq data for target validation and mechanism of action studies.
Provide technical oversight and leadership in vector design for mammalian display and antibody expression, library design, phage display, humanization, and affinity maturation.
Participate in multi-departmental research and development projects and discussions, providing scientific leadership and direction regarding activities related to molecular biology and target validation.
Act as in-house expert in matters related to molecular biology, antibody engineering, and antibody screening technologies.
Pro-actively assist others within Molecular Biology department in solving technical problems.
Partner with Protein Sciences and Cell Biology departments to ensure efficient antibody discovery, antibody affinity maturation, and protein production.
Coordinate experiments with colleagues and project team leaders to ensure rapid achievement of objectives and overall goals.
Proactively use literature to investigate and recommend new instruments and/or methods, screening strategies, or project targets.
Implement new methods, screening, and protocols as needed.
Direct process improvements for the group.
Ensure data generated is well-controlled and interpreted appropriately. Communicate findings, conclusions and potential strategies openly and effectively to colleagues and senior management.
Lead AnaptysBio projects with the goal of rapid identification of superior therapeutic candidates, to include:
Conceive strategies for developing new drug concepts through advancement of candidates to clinical development.
Lead project team meetings and coordinate activities for the project team with other research groups.
Write project reports and lead program reviews.
Perform and communicate background research within the therapeutic/project area, including design goals, lead identification strategy, competitive analysis and IP.
Stay current with the relevant scientific literature, and present and explain key concepts to colleagues.
Write and review manuscripts and intellectual property documents.
Participate in industry conferences and seminars with occasional travel required.
Follow and adhere to SOP's and laboratory safety regulations.
Knowledge Requirement

Practical knowledge of immunology.
Practical knowledge of surface display screening technologies.
Extensive experience with protein engineering.
Expertise in all aspects of antibody engineering, including humanization, sequence and affinity optimization, and design of multispecific antibodies.
Proficiency working with DNA analysis software programs such as Sequencher, DNAStar or their equivalent, and with Microsoft Office (Word, Excel, Powerpoint).

Personal Competencies

Solid background in scientific leadership with strong interpersonal and mentoring skills. Excellent collaborative skills for working on cross-functional multi-disciplinary teams.
Strong analytical and organizational skills, with high attention to detail. Capacity to prioritize assignments and work effectively under deadlines.
Strong communication skills, and ability to report and present experimental results and analysis to colleagues and senior management in a clear and concise manner.
Creates networks with key decision makers to effect change within the organization.
Intensely committed to success of the company and a job well done in a highly dynamic environment.
Self-motivated, independent, and results-oriented.
Physical Demands

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is regularly required to sit and talk or hear. The employee frequently is required to use hands to finger, handle, or feel. The employee is occasionally required to stand, walk, and reach with hands and arms. The employee must occasionally lift and/or move up to 10 pounds. Specific vision abilities required by this job include close vision and ability to adjust focus in order to read.

Work Environment

The work environment characteristics are representative of those an employee encounters while performing the essential functions of this job, typically in an open office environment. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

The noise level in the work environment is usually moderate. May be required to travel by plane or car.

This position requires working with biological and/or chemical hazards.

Requirements
Education & Experience

Ph.D. molecular biology, bioengineering, or related field with post-doctoral experience specializing in protein engineering or related.
10+ years, post-doctoral, of relevant experience with a minimum of 6 years industry experience in biotech and/or pharma.
Extensive background in biologics high throughput screening, protein engineering, protein structure and activity relationships, antibody generation and characterization, including humanization and affinity maturation.
Proven experience leading research programs aimed at identifying and optimizing candidate therapeutic proteins (preferably antibodies).
Demonstrated experience managing a group of molecular biologists involved in biologics discovery and protein engineering.

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