Scientist, Structural Biology

Foghorn Therapeutics
Cambridge, Massachusetts, US
May 05, 2021
May 29, 2021
Employment Type
Full time
Salary Type
About Foghorn

Foghorn Therapeutics is pioneering the discovery and development of a new class of medicines targeting genetically determined dependencies within the chromatin regulatory system, an untapped opportunity for therapeutic intervention. Our proprietary Gene Traffic Control® platform gives us an integrated, mechanistic understanding of how the various components of the chromatin regulatory system interact, allowing us to identify, validate and potentially drug targets within the system. The Company, currently in pre-clinical stage, is advancing over 10 small molecule and protein degrader programs across a wide range of cancers.

Foghorn was founded in 2016 by Cigall Kadoch, Ph.D., Gerald Crabtree, M.D., and Doug Cole, M.D., of Flagship Pioneering. Learn more about Foghorn at

About the Chromatin Regulatory System

The chromatin regulatory system regulates gene expression by directing the movement of molecules that turn genes on and off. Disease dependencies associated with the chromatin regulatory system are estimated to impact over 2.5 million cancer patients across the United States, Europe and Japan. This system is further implicated in neurological, autoimmune, and other serious diseases.


We are seeking a highly skilled and motivated structural biologist to become an integral member of the Foghorn team. This person will contribute to our goal of developing transformative therapeutics by planning and carrying out structural characterization of crucial drug targets. The main focus of this role will be protein crystallography but will require a willingness to find new ways to think about scientific challenges. We need someone who is passionate, driven, and ambitious to help us achieve our goal of improving patients' lives.

Responsibilities include:
  • Collaborating with colleagues in biochemistry, biology, and chemistry to develop structural biology strategy.
  • Designing biophysics-grade protein constructs and assisting in the optimization of purification protocols.
  • Crystallization, X-ray structure determination, and analysis of important drug targets.
  • Providing regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with medicinal and computational chemists.
  • Participating in the management of collaborations with contract research organizations (CROs) and academic partners.

  • PhD in Structural Biology, Biophysics, Biochemistry or a closely related field, with a background in chemistry
  • Demonstrated competency in protein construct design and expression and purification strategies using bacterial, insect, and mammalian hosts. Experience with multi-protein complexes is a plus.
  • Deep expertise in protein crystallization and X-ray structure determination of protein-ligand complexes
  • Extensive knowledge of protein structure and function, with the ability to articulately communicate structural information to a broad audience
  • Experience with other structural techniques (e.g. electron microscopy, small-angle X-ray scattering) is strongly preferred
  • Excellent time management and communication skills
  • Ability to work in a fast-paced, team-driven environment, with a collaborative and proactive attitude

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