Associate Director, Structural Biology

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

BMS is a leader in the discovery and development of novel therapies that exploit targeted protein degradation. Structural biology is critical to our protein homeostasis (PH) research. High quality 3D structures of proteins and protein complexes involved in UPS-mediated degradation help our scientists understand mechanism of action, design ligands or drug molecules, and make predictions about new biological targets for our drug discovery efforts. A deep focus in Oncology puts our resources squarely on projects of intense biomedical interest.

The team leader will direct the research of a talented group of structural biologists who have strong experience and skills in the PH field. There is opportunity to have high value impact in real time in ongoing projects as well as chart the future of our research efforts by capitalizing on structural insights (i.e., MOA, binding modes, degrons, etc.). The leader will interface with chemistry, biology, and CADD scientist working on our PH projects. There are additional opportunities to interact across our structural biology community of practice. The PH Structural Biology team will be part of an exciting and vibrant group that includes proteomics, biophysics, and cell biology that are dedicated to PH. We are seeking a passionate leader who wants to bring impactful structural biology insights to bear on a burgeoning portfolio of PH targets to help bring novel therapies to patients.

Job Responsibilities

Responsible for leading an internal team of 6-8 structural biologists working in PH

Lead / Contribute to the structural biology strategy for CRBN-mediated degradation of neosubstrates of interest.

Participate in a key alliance established to identify neosubstrates across cell lines representing human tumors and other diseases

Key contributor to leveraging PH-related CryoEM efforts via new collaboration with Princeton University

Plan, execute, and report on studies resulting in novel structures for CELMoDS and Ligand Directed Degraders (LDDs)

Lead structural biology efforts pursuing novel ligands for E3 ligases

Represent the PH Structural Biology at project level and departmental meetings

Lead and participate in departmental initiatives and represent PH Structural Biology on cross-functional initiatives / workstreams / taskforces

Interact closely with biology and chemistry on drug discovery teams

Work with Business Development teams and provide critical expertise to assess external opportunities

Provide mentorship and career development guidance to staff

Required Qualifications

A PhD with post-doctoral training structural biology

8+ years of experience in an industrial setting solving complex protein structures

In-depth knowledge of current practices and issues in X-Ray, Cryo-EM and other techniques

Working knowledge of proteomics, protein expression, biophysics, biochemistry and bioassay development

Strong written and oral communication skills necessary to deliver scientific results and presentations clearly

Demonstrated ability to work in a multidisciplinary team

Keen desire to grow and develop the careers of team members

Preferred Qualifications

Deep experience in the structural aspects of protein degradation pathways is strongly preferred

Travel Required

Local and international travel for conferences may be required depending on project needs up to 5% of the time

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.