Senior Principal Scientist/Principal Scientist, Large Molecule Biology, Team Leader

Employer
Loxo Oncology, Inc.
Location
Chelsea and Clinton, New York, US
Salary
Competitive
Posted
May 01, 2021
Closes
May 11, 2021
Ref
2152791821
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
The Senior Principal Scientist/Principal Scientist will lead a dynamic group of scientists (internal team as well as external CRO) conducting various research projects to identify large molecule/biologics which can effectively treat various forms of cancer. This is a hands-on role where you will lead from the bench. The Senior Principal Scientist/Principal Scientist will design and perform experiments that determine the efficacy of pipeline agents through a variety of techniques such as in vitro and ex vivo assays, target validation, and functional screening. Collaboration across functional areas within Loxo Oncology at Lilly is required including Large Molecule and Oncology Biologics senior leadership. The Senior Principal Scientist/Principal Scientist will be a key member of the large molecule organization, where you will be responsible for maintaining the scientific quality and efficiency of your organization, as well as assist and contribute to the strategic direction of large molecule discovery.

Roles and Responsibilities of the Position

Design and oversee the execution of key mechanistic and discovery biology experiments involving diverse oncogenic mechanisms (i.e., tumor indications, signaling, cancer targets, biologic mechanisms of tumor inhibitions).
Maintain focus on project deliverables and prioritize experiments and efforts accordingly.
Oversee/perform assays to identify the drug candidate evaluate the candidate for clinical testing.
Liaise with CROs and vendors to outsource activities, provide input to management team on vendor selection.
Provide scientific expertise when determining organizations to strategically partner with.
Interrogate experimental conduct of third parties/vendors.
Participate in target identification in collaboration with leadership.
Build, lead, and manage team of Scientists at various levels.
Indirectly oversee work of third parties/vendors (e.g., CROs).
Manage resource allocation effectively.
Build roadmaps to execute on specific targets, and overall strategic projects.

Required Qualifications and Background

PhD in cellular biology, immunology, or allied disciplines with minimum 3+ years' industry experience OR BS/MS with 10+ years of direct pharmaceutical/biotechnology experience.
Laboratory experience with ADC and CD3 platforms and biologic assays.
Knowledge on immune targets and myeloid biology/targets.
Strong attention to detail and highly goal oriented with demonstrated critical thinking capabilities.
Ability to trouble shoot effectively and think outside of the box.
Ability to collaborate with translational biology functions (PK/PD, toxicology, Ab discovery).
Proven success leading, managing, and coaching others (either directly or indirectly).
Demonstrated ability and track record in managing work overseen by third parties/vendors/strategic partners.
Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business.
Demonstrated excellence in making key strategic decisions in support of broader business goals.
Excellent written and verbal communication skills.

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