Cardiovascular Biologist, Therapeutic Discovery

Employer
StrideBio, Inc.
Location
Durham, North Carolina, US
Salary
Competitive
Posted
Apr 28, 2021
Closes
May 12, 2021
Ref
2016136907
Discipline
Project Management
Employment Type
Full time
Salary Type
Salary
StrideBio is a product-driven, fully integrated gene therapy company focused on creating and developing innovative genetic medicines with life-changing or curative potential for patients with devastating conditions, including monogenic rare disease and beyond.

We leverage our proprietary structure-inspired adeno-associated virus (AAV) vector engineering platform (STRIVE) to create unique and differentiated vectors that improve upon naturally occurring AAV serotypes to overcome current limitations of first-generation gene therapies. Combined with our genetic construct design expertise and in-house manufacturing capabilities, StrideBio is positioned to generate best-in-class genetic medicines that allow more patients to benefit with maximum efficiency, leading to improved treatment outcomes.

Our team is comprised of accomplished leaders and talented, passionate colleagues with a desire to translate innovative science into treatments. Together with our collaborators we are making rapid progress on our mission to bring novel medicines to patients who desperately need them. StrideBio's offices, labs and manufacturing facility are located in the heart of Research Triangle Park, NC, within 10 miles of downtown Durham and Raleigh-Durham International Airport. Please visit www.stridebio.com to learn more.

POSITION SUMMARY:

We seek a motivated Cardiovascular Biologist to join the Therapeutic Discovery group. This is a chance to help shape the company's future pipeline, as you will be involved in discovering and leading new cardiovascular disease programs. You will utilize your talents to perform cutting-edge research to generate data that will drive decisions around new disease opportunities. Your primary role will be to manage external research collaborations, while multi-tasking internal studies to evaluate different disease targets.

You will lead one or more projects and/or programs to enable the discovery and evaluation of novel rAAV therapies. You will be expected to drive scientific strategy, manage in vivo cardiovascular studies, and independently design and execute experiments using a wide variety of cell and molecular biology techniques in order to test the therapeutic potential of rAAV vectors. This position requires a strong cardiovascular physiology background. This is an approximate 50% lab-based position in a BSL II material laboratory.

MAJOR RESPONSIBILITIES:
  • Act as the scientific lead on one or more cardiovascular disease programs
  • Manage in vivo cardiovascular disease studies with academic collaborators and CROs
  • Independently design and execute various cell-based assays using iPSC-derived cardiomyocytes
  • Contribute to and drive scientific strategy for Therapeutic Discovery programs
  • Independently analyze and interpret data and present results to project teams

ADDITIONAL RESPONSIBILITIES:
  • Develop and optimize mRNA (qPCR), protein (ICC) and functional assays (calcium imaging, multi-electrode arrays)
  • Conduct molecular cloning and preparation of rAAV transgene constructs
  • Contribute to technology development related to cell biology
  • Ensure accurate and up-to-date records of laboratory activities via electronic documentation
  • Technical writing of procedures, protocols, and reports

REQUIRED TRAINING AND SKILLS:
  • Ph.D. in molecular or cell biology / physiology or other relevant scientific area, with minimum 3+ years' experience
  • Expertise in mechanisms of cardiovascular physiology and pathophysiology
  • Knowledge of in vivo cardiovascular disease models and endpoints (echocardiogram and electrocardiogram)
  • Strong written and verbal communications, including critical thinking skills
  • Demonstrated experience effectively managing multiple projects and staff and troubleshooting experiments
  • Demonstrated problem-solver who thrives on solving scientific challenges
  • Self-motivated and driven professional who can effectively perform in a rapidly changing, start-up environment
  • Must be able to work independently, but is also a team player with strong collaborative skills
  • Strong attention to detail, along with strong organizational and documentation skills

PREFERRED SKILLS:
  • Previous drug discovery and project management experience is desired
  • Relevant knowledge and industrial experience in the field of gene therapy development is preferred
  • Calcium imaging, multi-electrode arrays and whole-cell patch-clamp recordings in cardiomyocytes
  • Molecular cloning experience


COMPENSATION & BENEFITS:

We offer a competitive salary and excellent benefits package including:
  • Stock Options and Bonus
  • Medical, Dental, and Vision health insurance
  • Matching 401k plans (both Pre-tax and Roth Post-tax)
  • Life/AD&D, Long-term and Short-term disability
  • Employee Assistance Program
  • Voluntary: Supplemental Life, Critical Illness, Group Accident, Hospital Indemnity, Identity Theft Protection

Additionally, we provide the following perks:
  • Relocation Services
  • Retail Member Discount Programs
  • Complimentary onsite gym membership
  • Fully stocked kitchen
  • Socials, happy hours, and other events throughout the year (currently "virtual")

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