Scientist III, Cell Biology

4 days left

Employer
Thermo Fisher Scientific
Location
Carlsbad, California, US
Salary
Competitive
Posted
Apr 28, 2021
Closes
May 17, 2021
Ref
1846286132
Employment Type
Full time
Salary Type
Salary
Position Objective
This scientist will be:
- Working at the forefront of protein and cell analysis, developing reagents, tools, analytics and workflows to analyze the cellular transcriptome, particularly at the level of the 'single cell'.
- Providing technical insight to an extended team with respect to current directions in this field.
- Developing reagents aimed at enabling the understanding the single cell transcriptome using advanced sequencing and/or imaging techniques.
- Driving technical innovation in these areas.
- Participating as a team member in product development programs from conception (ideation), through development (innovation) and launch (commercialization).
- Supporting 'voice of customer' and lead 'beta-testing' programs.
- Generating application data that demonstrates the utility and performance of these products in workflows associated with oncology and immunology research.
- Working independently and as part of a team of scientists that will collaborate with a cross-functional team to achieve these goals.
Scope of Need
The successful individual will:
- Understand, troubleshoot and optimize single cell preparations that support molecular analysis, input to NGS library preparation and sequencing and protein analysis.
- Directly interact with senior R&D leadership, product management and project management to develop and execute project plans that support product development initiatives aimed at analyzing the transcriptome at the 'single cell' level.
- Deliver on goals according to a planned set of milestones, deliverables and timelines.
- Create intellectual property.
- Provide a significant level of independence and strong teamwork.
This role may involve any of the following tasks:
- Cell biology: Culture of immortalized, primary and engineered cell types
- Sample preparation: Optimizing isolation, fixation and permeabilization of single cells
- Cell analysis: Use of PCR, gene expression, sequencing, imaging and flow cytometry
- Sequencing: Use of Next Generation Sequencing techniques
- Biochemistry: Application of chemistry to identify bio-molecules within cells
- Periodic weekend work: 'As needed' based on schedule and lab density requirements
Education:
Prefer a PhD degree in cell biology, molecular and cell biology, immunology, oncology or related field.
Candidates with a bachelor's degree (5+ years experience) or a master's degree (3+ years experience) may be considered.
Knowledge, Skills, Abilities
- Perform standard laboratory math calculations and solutions/media preparation
- Ability to culture wide variety of cell types including immortalized, primary and engineered
- Ability to optimize cell isolation, preparation, fixation and permeabilization for molecular analysis
- Use of single cell analysis techniques, especially single cell RNAseq and flow cytometry
- Use of Next Generation Sequencing acquisition and analysis
- Use or understanding of bio-informatics for large data set analyses
- Observe deviations from the expected outcomes
- Succeed with a moderate level of supervision and guidance
- Work within a strong team with demonstrable influence/interpersonal skills
- Experience in a biotechnology commercial environment would be a differentiator
Experience:
- Required: 3-5 years experience in cell biology
- Required: 2+ years experience in oncology or immunology
- Required: 2+ years experience with single cell analysis techniques (esp. sequencing)
- Preferred: 1-2 years experience in molecular biology
- Preferred: Use of bio-informatics analysis applied to sequencing or cellular analysis
- Preferred: 1+ years experience with automation or high-throughput applications
Working Conditions:
- Majority of working time will be spent manipulating cells in order to study DNA, RNA or protein in a laboratory environment.
- Significant work may take place in biosafety hoods in a tissue culture laboratory, working with various cell cultures.
- Cells will be isolated and optimized for analysis by molecular biology, sequencing techniques or protein assays.
- Recording laboratory activities appropriately in notebooks.
- Must be capable of observing and adhering to lab safety standards and protocols.
- Must be able to identify deviations from expected outcomes and participate in trouble-shooting those deviations and suggesting alternatives.
- Critical to success in this position will be the individual's ability to work independently and to work as part of a high-performing team.
- Must be able to work as part of a team in the laboratory (extended R&D team) and as part of a broader cross-functional team (R&D, Project Management, Product Management, Quality, Operations, Marketing, Commercial).
- Occasional weekend work may be required to maintain current social distancing guidelines and project schedules.
Thermo Fisher Scientific is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, creed, religion, color, national or ethnic origin, citizenship, sex, sexual orientation, gender identity and expression, genetic information, veteran status, age or disability status.

Similar jobs

Similar jobs