Senior Director/Executive Director, Cancer Biology and Translational Research

Employer
TP Therapeutics
Location
San Diego, California, US
Salary
Competitive
Posted
Apr 28, 2021
Closes
May 11, 2021
Ref
2123113743
Discipline
Biology, Genetics
Employment Type
Full time
Salary Type
Salary
Turning Point Therapeutics is a public, clinical-stage precision oncology company with three molecules in clinical development and one in IND-enabling studies. Our internally discovered investigational drugs are designed to address key limitations of existing cancer therapies. We are applying a highly refined design methodology anchored by deep SBDD expertise coupled with a disciplined chemistry approach and enabling biology expertise to build upon our early portfolio. Our Research organization has the exciting task of discovering new investigational molecules and identifying new clinical opportunities for our existing pipeline molecules. We seek talented, committed cancer researchers to join our growing team and develop transformational therapies for cancer patients

DUTIES AND RESPONSIBILITIES

Senior role in Turning Point Therapeutics' Research organization that ensures the delivery of a robust preclinical pipeline of high-value, novel oncology small molecule inhibitors spanning from Target ID/Validation to IND submission.
Lead a team of in-house researchers to support drug discovery and translational research
Communicates science and strategy effectively in a variety of internal and external settings
Devises and executes cancer biology experiments to support projects from validation to clinical candidate selection
Ensures timely delivery of incisive and actionable biology data that defines/refines drug discovery strategy
Manages the work of multiple internal biologists and leverages CROs and academic collaborators effectively to drive program science forward
Maintains high-functioning and synergistic cross-functional collaborations across the Turning Point Therapeutics discovery organization.
Participates in competitive intelligence, as well as scientific and clinical knowledge management, to track advances in relevant therapeutic areas, by interacting with external experts, attending scientific meetings, and staying abreast of the literature.
Furthers Turning Point Therapeutics' culture of scientific excellence and achievement as well as champions the career growth of a talented team of cancer biologists.
Develop and coach a team of research scientists
Responsible for creating pharmacology sections of regulatory documents such as IND and NDA

DESIRED SKILLS AND EXPERIENCE

A degree in Biology or related field (Ph.D., M.D.) with at least 15 years of drug discovery experience in either a biotech or pharmaceutical industry setting
Demonstrated drug discovery project leadership experience on target identification strategies including the design, execution and validation of targets from genetics/CRISPR/Multi-omics/phenotypic screen.
Extensive experience in oncology small molecule drug discovery
Expertise in cell signaling and identification of molecular correlates of drug response
Strong command of various omics platforms and systems biology to garner an integrated understanding of cancer cell signaling
Working knowledge of proteomics to identify signaling networks, target sCompanytrates to id/validate PD biomarkers and its implementation in the clinic
Demonstrated success in building and supporting patient selection hypotheses that have defined the clinical strategy for targeted small molecule oncology therapeutics
Success leading project teams from target validation through IND filing.
Strong publication record.
Strong communication skills (oral and written)
Working knowledge of chemistry, structure-based drug design, mechanisms of drug metabolism and toxicology, drug delivery methods, pharmacokinetics, and pharmacodynamic sciences that support in vivo evaluation of drug candidates is desirable.
Work closely with project teams, play a leadership role in developing preclinical data sets to inform target Organizationality, patient stratification and rational combination strategies for novel therapeutics is desirable
A desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families, and society
Must be a creative, organized, strategic, motivated self-starter, capable of driving Turning Point's discovery biology efforts.

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