Research Associate II, Genomics and Molecular Biology

CRISPR Therapeutics
Cambridge, Massachusetts, US
Apr 28, 2021
May 09, 2021
Employment Type
Full time
Salary Type
Company Overview

At CRISPR Therapeutics, we are focused on developing transformative gene-based medicines for serious human diseases. We are rapidly translating our CRISPR/Cas9 gene editing platform into therapies to treat hemoglobinopathies, cancer, diabetes, and other diseases. Our multi-disciplinary team of world-class researchers and drug developers is committed to translating CRISPR/Cas9 technology into breakthrough human therapeutics. Our lead program targeting the blood diseases β-thalassemia and sickle cell disease has entered clinical testing, and our immuno-oncology programs focused on CRISPR/Cas9-edited allogeneic CAR-T cell therapies have the potential to deliver the next generation of cancer therapies to patients.

Job Summary

We are seeking a Research Associate II to join our genomics laboratory group. The successful candidate will be responsible for performing quality control experiments on nucleic acids and converting DNA and RNA into sequencing libraries using a variety of methods and liquid automation tools. The successful candidate will interact and closely work with therapeutic scientists, computational biologists, and the genomic laboratory group regarding projects, samples, and timelines. This position requires enthusiasm, attention to detail, and a desire to create new medicines for patients. This position reports directly to the head of the genomics laboratory group.

  • Track sample data and project timelines through a laboratory information management system (LIMS) and electronic laboratory notebook (ELN)
  • Extract nucleic acids from cells and tissues and perform routine quality control experiments on nucleic acid samples
  • Transform nucleic acid samples into sequencing libraries through a variety of methods by hand and robotic liquid handlers
  • Apply operational knowledge of instruments used in the genomics space ( e.g. TapeStation, Bioanalyzer, optical plate reader, robotic liquid handling, and Illumina sequencers)
  • Help maintain instrumentation and laboratory facilities; troubleshoot instrument issues
  • Flexibly and effectively communicate within the genomics group and across functional teams to ensure timely completion of concurrent projects

Minimum Qualifications
  • BS in biology or related discipline and 3+ years of experience at academic or industrial genomic core labs
  • Experienced in sequencing library preparation starting from RNA and DNA and proficient in general molecular biology
  • Experience using LIMS to document experimental metadata
  • Excellent organizational and communication skills
  • Experience working collaboratively with wet and dry lab scientists, and understanding large data sets
  • Ability to think strategically, efficiently manage time and workflows, and work both independently and collaboratively
  • Track record of challenging oneself to enhance professional and scientific skills and knowledge

Preferred Qualifications
  • Experience working in biotech industry
  • Experience with Hamilton instrumentation, Illumina BaseSpace, and Veeva software
  • Experience conducting high-throughput genomic assays and single cell genomic assays
  • Experience with NGS-based assay development
  • Experience working with GMP-grade samples and clinical samples

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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