Scientist II/ Senior Scientist I, Chemical Biology

3 days left

Employer
AbbVie
Location
North Chicago, Illinois, US
Salary
Competitive
Posted
Apr 28, 2021
Closes
May 15, 2021
Ref
2137727872
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter (https://twitter.com/abbvie) , Facebook (https://www.facebook.com/AbbVieGlobal) , Instagram (https://www.instagram.com/abbvie/?hl=en) , YouTube (https://www.youtube.com/user/AbbVie) and LinkedIn (https://www.linkedin.com/company/abbvie) .
We are seeking a multidisciplinary scientist to join the Discovery Platform and Technologies (DPT) department with a specific focus on target identification and characterization, as well as quantifying drug candidate target engagement and selectivity. The successful candidate will be adept in using chemical biology techniques combined with analytical tools for addressing drug discovery program needs within the Chemical Biology and Emerging Therapeutics team. The successful candidate will also identify novel technologies and develop methods to improve detection methods and enhance assay readouts to support AbbVie's drug discovery pipeline while interacting with a broad range of therapeutic area scientists to deliver key data that accelerates the delivery of novel medicines to patients in need.
Key Responsibilities:
- Conceptualize, plan, and execute experiments to identify drug candidate targets and off-targets, quantify target engagement, and characterize biological pathway changes relevant to potential mechanisms of action
- Utilize cell culture hoods, cell incubators, and related equipment to execute in vitro experimental work
- Prepare samples from cells and tissues for multiple downstream analyses such as immunoassays (e.g., Western blot, ELISA, TR-FRET), mass spectrometry, and nucleic acid sequencing
- Propose and evaluate novel methods and technologies for improved target detection and monitoring
- Interface and collaborate with colleagues and project teams in therapeutic areas to determine appropriate chemical biology approach to best address the need
- Engage in external collaborations where opportunities align with team mission
- Serve as lead author on external publications
Qualifications
Position will be hired based on level of experience.
- BS, MS or PhD in chemical biology, molecular/cell biology, pharmacology, or related area with typically 8-10+ (BS), 6-8+ (MS), or 0+ (PhD) years of experience.
- Experience with cell culture, tissue homogenization, protein enrichment, and sample handling
- Experience with standard analytical protein monitoring assays (e.g., Western blot, ELISA, luminescence, immunofluorescence)
- Able to integrate multiple sources of data, perform biological pathway analyses, and interpret results to produce meaning from experimental outputs
- Strong knowledge of small molecule-protein interactions and biological pathway and disease biology (e.g., oncology, neurodegeneration, immunology, etc...)
- Effective verbal and written communication skills with a strong publication and/or speaking record with an emphasis on novel scientific approaches
- Can-do attitude/team-oriented/open to tackling new challenges
- High attention to detail, creativity in problem-solving, strong interpersonal skills, and ability to successfully work independently
Preferred:
- Experience in proteomics (sample preparation, data acquisition, data analysis) and next-generation sequencing (DNA/RNA isolation and data analysis)
- Experience with liquid handling or other lab automation systems
- 1-3+ years industry experience
Key Leadership Competencies:
- Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
- Learns fast, grasps the 'essence' and can change the course quickly where indicated
- Raises the bar and is never satisfied with the status quo
- Creates a learning environment, open to suggestions and experimentation for improvement
- Embraces the ideas of others, nurtures, and manages innovation to reality
Significant Work Activities
N/A
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

Similar jobs

Similar jobs