Scientist, T Cell Biology

4 days left

Employer
Alloy Therapeutics
Location
Lexington, Massachusetts, US
Salary
Competitive
Posted
Apr 28, 2021
Closes
May 15, 2021
Ref
2080440704
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
Scientist, T Cell Biology - Lexington, MA

APPLY HERE: https://alloytherapeutics.applytojob.com/apply

About Alloy Therapeutics

Alloy Therapeutics is a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. We provide affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. Our lead offering, the ATX-Gx™ platform, is a human therapeutic antibody discovery platform consisting of a growing suite of proprietary transgenic mice strains. Founded in 2017 and privately funded by visionary investors, we are headquartered in Boston, MA with European labs in Cambridge, UK. As a reflection of our relentless commitment to the scientific community, Alloy reinvests 100% of its revenue in innovation and access to innovation.

At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. The team and company are rapidly expanding; successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

MAY THE BEST DRUG WIN.

About Scientist, T Cell Biology - Lexington, MA

Our Alloy Discovery Services group is looking for a Scientist to join our team in Lexington, Massachusetts. The position will report directly to our Director of External Discovery & Innovation and work with our Discovery Services team to support the discovery and functional characterization of antibody-based therapeutics, effector cell engagers, chimeric receptors, and TCR-based therapeutics. You will be using the latest in cell-based functional assays to develop screening methods for molecules characterized by the best functionality and potency with the ultimate goal of helping others to make better medicines.

Principal Responsibilities
  • Development and optimization of cell-based activity assays for primary and engineered human immune cells (T cells, NK cell, Macrophages)
  • Engineering of CAR T and NK cells using viral vectors or other gene editing approaches
  • Expansion and analysis of genetically modified primary T cells and other immune cells
  • Optimization of gene editing in primary immune cells using the CRISPR Cas9 system
  • Utilize an array of analytical and molecular techniques, next generation sequencing, to understand the dynamics and response of genetically modified T cells and other immune cells to antibody-based therapeutics
  • Effectively collaborate within Alloy's team and with external partners to develop study design and obtain test materials and reagents
  • Contribute to study design, execution, and data analysis
  • Compile and present data to functional teams
  • Being generous when others are needy, greedy or fearful


Required Qualifications and Skills
  • PhD or MS in cell biology, immunology, or related discipline with 5+ years' experience
  • Experience with mammalian cell culture; isolation, handling, and characterization of primary human immune cells
  • Experience with standard immunological assays (e.g. activation markers, cytokine release, cell killing; flow cytometry, MSD/Luminex and other methods)
  • Experience working with automated HTP liquid handlers is a plus
  • Competency in basic molecular biology techniques, including cell line engineering
  • Working knowledge of various software (e.g. FlowJo, GraphPad Prism, FACSDiva, Geneious)
  • A sense of urgency, speed and persistence


Benefits Include
  • Competitive base salary based on the position and your experience level
  • Significant opportunities for advancement inside Alloy and through our partner companies
  • Equity compensation in a company with incredible growth potential and a 30+ year plan
  • Generous personal and family medical, dental and vision benefits with 90% of premiums and deductibles covered by Alloy
  • Flexible schedule, unlimited vacation as long as the job gets done, medical leave including time caring for sick family members, and parental leave all built around our team-driven philosophy
  • Commitment to your career through individualized professional development plan for all employees to ensure good role and skill fit either at Alloy or your next biotech company
  • Additional benefits including adoption support, IVF/PGT support, compensated time for bone marrow donation, continuing education, leadership development and others


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