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Scientist Translational Biology

Employer
Codexis
Location
Redwood City, California, US
Salary
Competitive
Closing date
Jul 30, 2021

View more

Sector
Academic / Research
Field
Conservation science
Discipline
Biology
Salary Type
Salary
Employment Type
Full time
Are you ready to join our mission to fight rare diseases? Do you have a passion to help people have better quality of life? Come be part of the Codexis, Inc team where every day we get to unlock the power of proteins ® !

Codexis's Biotherapeutics division uses our world-leading CodeEvolver® protein engineering platform to discover novel therapies for the treatment of genetic disorders and other debilitating disease. We engineer proteins with high efficacy and safety with the goal of delivering the therapeutic to patients as an enzyme replacement, mRNA, or gene therapy.

But we can't do it without YOU!

Codexis Biotherapeutics is rapidly growing, and we are presently seeking to expand our pipeline and diversify applications of our technology platform. To help us meet our goals, we are looking to hire a Scientist I to join our Biotherapeutics Translational Biology team.

If any of the below describes you, we would love to meet you!
  • Passionate about large-molecule drug discovery to improve the quality of life for patients with rare diseases
  • Experienced or interested in novel technologies for protein engineering and directed evolution.
  • Excited about developing appropriate pharmacodynamic and pharmacokinetic studies, and models of disease to show efficacy, in order to progress variants into clinical development.

In this role you will be responsible for:
  • Design and execution of PK/PD and efficacy studies, management of animal colonies where appropriate.
  • Identifying, developing, and managing external collaborators (academic, industrial partners, and CROs) to support preclinical development programs. Collaborate with CRO's/KOL's to develop animal models relevant to programs.
  • Understand and support/conduct the in vitro assays necessary to move programs forward, participate where appropriate in design.
  • Identification and validation of translational biomarkers ahead of moving to clinical trials.
  • Maintaining a current understanding of the scientific literature related to rare diseases where therapeutic enzymes and proteins could be impactful.
  • Representing the Translational Biology group within project teams.
  • Reviewing and analyzing scientific literature to identify opportunities and liabilities for protein therapeutics.
  • Excellent and effective oral and written communication with Codexis R&D, senior leadership, and external collaborators.
  • Preparing and editing nonclinical documents for regulatory submission.
  • Participation in discussions with KOL's to obtain feedback on preclinical development programs.


To be successful in this role, your background and experience should include:
  • PhD preferably in Biology or Pharmacology plus 2+ years' experience in preclinical drug development.
  • Hands-on experience with in vivo pharmacology highly desired, as well as experience in inborn errors of metabolism, gastrointestinal disorders, as well as rare diseases where enzymes/proteins are therapies.
  • Experience in designing, conducting, monitoring, and interpreting non-clinical efficacy studies with emphasis on translational biomarkers.
  • An excellent scientific background as demonstrated through publications in top peer- reviewed journals.
  • Successful track record of leading consultants, academic collaborations, and CROs.


What can Codexis offer you? (besides an amazing and collaborative culture?
  • Full benefits on your first day
  • 100% match on the first 4% of your 401k contribution
  • Generous flex time off
  • Fitness reimbursement
  • Free fitness classes
  • Back up child/dependent care
  • Commuter vouchers
  • Much more!
PRINCIPALS ONLY
NO AGENCIES OR THIRD PARTIES

Codexis is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.

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